A radiomics-based model for the outcome prediction in COVID-19 positive patients through deep learning with both longitudinal chest x-ray and chest computed tomography images

The coronavirus disease 2019 (COVID-19) pandemic had a major impact on global health and was associated with millions of deaths worldwide. During the pandemic, imaging characteristics of chest X-ray (CXR) and chest computed tomography (CT) played an important role in the screening, diagnosis and monitoring the disease progression. Various studies suggested that quantitative image analysis methods including artificial intelligence and radiomics can greatly boost the value of imaging in the management of COVID-19. However, few studies have explored the use of longitudinal multi-modal medical images with varying visit intervals for outcome prediction in COVID-19 patients. This study aims to explore the potential of longitudinal multimodal radiomics in predicting the outcome of COVID-19 patients by integrating both CXR and CT images with variable visit intervals through deep learning. 2274 patients who underwent CXR and/or CT scans during disease progression were selected for this study. Of these, 946 patients were treated at the University of Pennsylvania Health System (UPHS) and the remaining 1328 patients were acquired at Stony Brook University (SBU) and curated by the Medical Imaging and Data Resource Center (MIDRC). 532 radiomic features were extracted with the Cancer Imaging Phenomics Toolkit (CaPTk) from the lung regions in CXR and CT images at all visits. We employed two commonly used deep learning algorithms to analyze the longitudinal multimodal features, and evaluated the prediction results based on the area under the receiver operating characteristic curve (AUC). Our models achieved testing AUC scores of 0.816 and 0.836, respectively, for the prediction of mortality. © 2023 SPIE.

Automatic Detection of Lung Ultrasound Artifacts using a Deep Neural Networks approach

The COVID-19 pandemic has challenged many of the healthcare systems around the world. Many patients who have been hospitalized due to this disease develop lung damage. In low and middle-income countries, people living in rural and remote areas have very limited access to adequate health care. Ultrasound is a safe, portable and accessible alternative;however, it has limitations such as being operator-dependent and requiring a trained professional. The use of lung ultrasound volume sweep imaging is a potential solution for this lack of physicians. In order to support this protocol, image processing together with machine learning is a potential methodology for an automatic lung damage screening system. In this paper we present an automatic detection of lung ultrasound artifacts using a Deep Neural Network, identifying clinical relevant artifacts such as pleural and A-lines contained in the ultrasound examination taken as part of the clinical screening in patients with suspected lung damage. The model achieved encouraging preliminary results such as sensitivity of 94%, specificity of 81%, and accuracy of 89% to identify the presence of A-lines. Finally, the present study could result in an alternative solution for an operator-independent lung damage screening in rural areas, leading to the integration of AI-based technology as a complementary tool for healthcare professionals. © 2023 SPIE.

Semi-Supervised Modified-UNet for Lung Infection Image Segmentation

Automatic lung infection segmentation in computed tomography (CT) scans can offer great assistance in radiological diagnosis by improving accuracy and reducing time required for diagnosis. The biggest challenges for deep learning (DL) models in segmenting infection region are the high variances in infection characteristics, fuzzy boundaries between infected and normal tissues, and the troubles in getting large number of annotated data for training. To resolve such issues, we propose a Modified U-Net (Mod-UNet) model with minor architectural changes and significant modifications in the training process of vanilla 2D UNet. As part of these modifications, we updated the loss function, optimization function, and regularization methods, added a learning rate scheduler and applied advanced data augmentation techniques. Segmentation results on two Covid-19 Lung CT segmentation datasets show that the performance of Mod-UNet is considerably better than the baseline U-Net. Furthermore, to mitigate the issue of lack of annotated data, the Mod-UNet is used in a semi-supervised framework (Semi-Mod-UNet) which works on a random sampling approach to progressively enlarge the training dataset from a large pool of unannotated CT slices. Exhaustive experiments on the two Covid-19 CT segmentation datasets and on a real lung CT volume show that the Mod-UNet and Semi-Mod-UNet significantly outperform other state-of-theart approaches in automated lung infection segmentation. IEEE

Classic Augmentation based Classifier Generative Adversarial Network (CACGAN) for COVID-19 Diagnosis

Computer-aided diagnosis of COVID-19 from lung medical images has received increasing attention in previous clinical practice and research. However, developing such automatic model is usually challenging due to the requirement of a large amount of data and sufficient computer power. With only 317 training images, this paper presents a Classic Augmentation based Classifier Generative Adversarial Network (CACGAN) for data synthetising. In order to take into account, the feature extraction ability and lightness of the model for lung CT images, the CACGAN network is mainly constructed by convolution blocks. During the training process, each iteration will update the discriminator's network parameters twice and the generator's network parameters once. For the evaluation of CACGAN. This paper organized multiple comparison between each pair from CACGAN synthetic data, classic augmented data, and original data. In this paper, 7 classifiers are built, ranging from simple to complex, and are trained for the three sets of data respectively. To control the variable, the three sets of data use the exact same classifier structure and the exact same validation dataset. The result shows the CACGAN successfully learned how to synthesize new lung CT images with specific labels. © 2023 SPIE.

Comparative Analysis of Laboratory and Radiation Methods of Studies with the Degree of Severity of Patients with COVID-19

The study is devoted to a comparative analysis and retrospective evaluation of laboratory and instrumental data with the severity of lung tissue damage in COVID-19 of patients with COVID-19. An improvement was made in the methodology for interpreting and analyzing dynamic changes associated with COVID-19 on CT images of the lungs. The technique includes the following steps: pre-processing, segmentation with color coding, calculation and evaluation of signs to highlight areas with probable pathology (including combined evaluation of signs). Analysis and interpretation is carried out on the emerging database of patients. At the same time the following indicators are distinguished: the results of the analysis of CT images of the lungs in dynamics;the results of the analysis of clinical and laboratory data (severity course of the disease, temperature, saturation, etc.). The results of laboratory studies are analyzed with an emphasis on the values of the main indicator - interleukin-6. This indicator is a marker of significant and serious changes characterizing the severity of the patient's condition. © 2023 IEEE.

Linking CT and SPECT based analysis for quantitative follow-up of vascular perfusion defects in COVID-19

COVID-19 still affects a large population worldwide with possible post-traumatic sequelae requiring long-term patient follow-up for the most severe cases. The lung is the primary target of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infection. In particular, the virus affects the entire pulmonary vascular tree from large vessels to capillaries probably leading to an abnormal vascular remodeling. In this study we investigated two modalities for assessing this remodeling, SPECT perfusion scintigraphy and computed tomography, the latter enabling the computation of vascular remodeling patterns. We analyzed on a cohort of 30 patients the relationship between vascular remodeling and perfusion defects in the peripheral lung area, which is a predominant focus of the COVID-19 infectious patterns. We found that such relationship exists, demonstrated by moderate significant correlations between SPECT and CT measures. In addition, a vascular remodeling index derived from the z-score normalized peripheral CT images showed a moderate significant correlation with the diffusing capacity of the lung for carbon monoxide (DLCO) measures. Altogether these results point CT scan as a good tool for a standardized, quantitative, and easy-to-use routine characterization and follow-up of COVID-19-induced vascular remodeling. An extensive validation of these results will be carried out in the near future on a larger cohort. © 2023 SPIE.

A Simulation of a Design and Implementation of a New Low- Cost Prototype Portable Smart Ventilator

The outbreak of the Covid-19 virus prompted many engineers and researchers around the world to seek to develop mechanical ventilation devices and make them easy to use and affordable. This paper presents a simulation model for a group of medical sensors and gives very accurate results. This model contributes to the development and improvement of the artificial breathing system by comparing the results between the simulation model and the realistic response of the human lung. © 2023 IEEE.

Development of an acquisition system to monitoring asynchronous tele-ultrasound for lung patients

Lung ultrasound imaging allows the detection and evaluation of the lung damage generated by COVID-19. However, several infrastructure and logistical limitations prevent them from being carried out in isolated and remote areas. In this work, a system for the acquisition of medical images through asynchronous tele-ultrasounds was developed. The system is based on a graphical user interface, which records the three video cameras, the ultrasound image and the accelerometer simultaneously. The interface was developed according to the Volume Sweep Imaging acquisition protocol. The translational and rotational movement of the transducer are tracked and monitored by the accelerometer and the position of the transducer is obtained from the images acquired by the three video cameras. The results show a correct functioning of the system overall, being viable to be implemented for data acquisition and calculation of error, although in order to validate the error calculation there is still more research to be done. © 2023 SPIE.

An observer comparison study to evaluate a machine learning model to quantify the infected pneumonia on lung CT images

Quantification of infected lung volume using computed tomography (CT) images can play a critical role in predicting the severity of pulmonary infectious disease. Manual segmentation of infected areas from several CT image slices, however, is not efficient and viable in clinical practice. To assist clinicians in overcoming this challenge, we developed a new method to automatically segment and quantify the percentage of the infected lung volume. First, we used a public dataset of 20 COVID-19 patients, which consists of manually annotated lung and infection masks, to train a new joint deep learning (DL) model for lung and infection segmentation. As for lung segmentation, a Mask-RCNN model was applied to the lung volume with a novel postprocessing technique. Following that, an ensemble model with a customized residual attention UNet model and feature pyramid network (FPN) models was employed for infection segmentation. Next, we assembled another set of 80 CT scans of Covid-19 patients. Two chest radiologists manually evaluated each CT scan and reported the infected lung volume percentage using a customized graphical user interface (GUI). The developed DL-model was also employed to process these CT images. Then, we compared the agreement between the radiologist (manual) and model-based (automated) percentages of diseased regions. Additionally, the GUI was used to let radiologists rate acceptance of the DL-model generated segmentation results. Analyzing the results demonstrate that the agreement between manual and automated segmentation is >95% in 28 testing cases. Furthermore, >53% of testing cases received the top assessment rating scores from two radiologists (between four-five- score). Thus, this study illustrates the feasibility of developing a DL-model based automated tool to effectively provide quantitative evaluation of infected lung regions to assist in improving the efficiency of radiologists in infection diagnosis. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.

Identify Type of Lung Infection from Lung Patients X-RAY Image LIVERAGING Computer Vision

This research proposes a computer vision-based solutions to identify whether a patient is covid19/normal/Pneumonia infected with comparable or better state-of-The-Art accuracy. Proposed solution is based on deep learning technique CNN (Convolutional Neural networks) with multiple approaches to cover all open issues. First approach is based on CNN models based on pre-Trained models;second approach is to create CNN model from scratch. Experimentation and evaluation of multiple approaches helps in covering all open points and gaps left unattended in related work performed to solve this problem. Based on the experimentation results of both the approaches and study of related work done by other researchers, Both the approaches are equally effective can be recommended for multi-class classification of lung disease. © 2023 IEEE.

Efficient intelligent compression and recognition system-based vision computing for computed tomography COVID images

Computed tomography (CT) image-based medical recognition is extensively used for COVID recognition as it improves recognition and scanning rate. A method for intelligent compression and recognition system-based vision computing for CT COVID (ICRS-VC-COVID) was developed. The proposed system first preprocesses lung CT COVID images. Segmentation is then used to split the image into two regions: nonregion of interest (NROI) with fractal lossy compression and region of interest with context tree weighting lossless. Subsequently, a fast discrete curvelet transform (FDCT) is applied. Finally, vector quantization is implemented through the encoder, channel, and decoder. Two experiments were conducted to test the proposed ICRS-VC-COVID. The first evaluated the segmentation compression, FDCT, wavelet transform, and discrete curvelet transform (DCT). The second evaluated the FDCT, wavelet transform, and DCT with segmentation. It demonstrates a significant improvement in performance parameters, such as mean square error, peak signal-to-noise ratio, and compression ratio. At similar computational complexity, the proposed ICRS-VC-COVID is superior to some existing techniques. Moreover, at the same bit rate, it significantly improves the quality of the image. Thus, the proposed method can enable lung CT COVID images to be applied for disease recognition with low computational power and space. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JEI.32.2.021404] © 2023 SPIE. All rights reserved.

An Automated CHNN Model for the Classification and Detection of Lung Diseases using Transfer Learning

The COVID-19 pandemic began in December2019 and caused a global crisis. The WHO declared it a pandemic on March 11, 2020. Since October 10, 2020, COVID-19 has affected 200+ countries, causing over 37 million confirmed cases and 1 million deaths. RT-PCR is the usual method for detecting it, but it has drawbacks. Individuals who exhibit symptoms of COVID-19 but receive negative results from RT-PCR tests may be diagnosed with the disease using chest X-rays and CT scans, as these imaging techniques are capable of detecting lung abnormalities that are commonly associated with COVID-19, including consolidation and ground-glass opacities. The detection of COVID-19 systems faces numerous challenges, including false negatives, limited testing capacity, a scarcity of imaging equipment, and a shortage of data. With the increasing number of cases, there is a pressing need for a quicker, more cost-effective screening method. Chest X-ray scans can serve as a supplementary or confirming approach as they are fast and readily available. An Automated Hybrid Convolutional Neural network-Hopfield Neural Network (CHNN) is proposed in this study by extracting the features using VGG-19 for the classification and detection of lung diseases. In this work, both two-fold and multi-class classifications have been done with 99% and 97% accuracy respectively. © 2023 IEEE.

Application of Convolutional Neural Network techniques to the classification of lung illnesses

The heterotypic perspective of cancer depicts solid tumors as ecosystems composed of aberrant epithelium tumor cells and a multitude of cell types together referred to as stromal cells. Macrophages, which are innate immune cells, are overrepresented in certain environments. Tumor-associated macrophages (TAMs) are macrophages found in the tumor microenvironment;they are derived from the blood's monocytes and are essential for tumor progression. TAMs acquiring tumorigenic qualities is dependent on a complicated interaction between TAMs and tumor cells. Using co-culture studies, we showed that tumor-derived secretory signals promote Tams' tumor-promoting characteristics, shaping up Tams' features in ways that are advantageous to the tumor. When model human monocytes (THP-1) were co-cultured with A549 cells, the A549 cells exhibited increased proliferation, migration, and invasiveness due to the secretion of tumor-promoting cytokines from the THP-1 cells. We showed that EDA-containing Fibronectin secreted by A549 cells reliably mediates the pro-inflammatory response of THP-1 monocytes in a paracrine manner. Ablation of such responses by the treatment of THP-1 cells with TLR-4 blocking antibody implicated Fibronectin-TLR4 axis in tumor-associated inflammation and suggests a paradigm wherein lung carcinoma cell derived EDA-containing Fibronectin drives a pro-inflammatory and pro-metastatic tumor microenvironment. Interestingly, autocrine proliferation, migration, and invasion were all boosted by EDA-containing Fibronectin secreted by A549 cells. Lastly, we demonstrated that the EDA in Fibronectin activates the epithelial-mesenchymal transition pathway in A549 cells, hence granting these cells the ability to metastasize. © 2023 IEEE.

A DEEP LEARNING APPROACH LUNG SEGMENTATION AND PNEUMONIA DETECTION FROM X-RAYS

Lung segmentation is a process of detection and identification of lung cancer and pneumonia with the help of image processing techniques. Deep learning algorithms can be incorporated to build the computer-aided diagnosis (CAD) system for detecting or recognizing broad objects like acute respiratory distress syndrome (ARDS), Tuberculosis, Pneumonia, Lung cancer, Covid, and several other respiratory diseases. This paper presents pneumonia detection from lung segmentation using deep learning methods on chest radiography. Chest X-ray is the most useful technique among other existing techniques, due to its lesser cost. The main drawback of a chest x-ray is that it cannot detect all problems in the chest. Thus, implementing convolutional neural networks (CNN) to perform lung segmentation and to obtain correct results. The 'lost' regions of the lungs are reconstructed by an automatic segmentation method from raw images of chest X-ray. © 2022 IEEE.

Covid Analysis using Recurrent Neural Network

The examination of medical images has benefited greatly from the use of artificial intelligence. In contrast to deep learning systems, which do feature extraction automatically and without human interaction, traditional computer vision methods rely on manually produced features that are particular to a certain domain. Having access to medical information for automated analysis is another major factor driving the trend towards deep learning. Chest x-ray pictures are processed in order to segment the lungs and identify diseases in this thesis. Due to its cheap cost, ease of capture, and non-invasive nature, chest x-ray is the most often used medical imaging technology. However, automatic diagnosis in chest x-rays is difficult due to (1) the presence of the rib-cage and clavicle bones, which can obscure abnormalities that are located beneath them, and (2) the fuzzy intensity transitions near the lung and heart, dense abnormalities, rib-cages, and clavicle bones, which make the identification of lung contours subtle. In x-ray image processing, the Convolutional Neural Network (CNN) is the most often used deep learning architecture. Because to the enormous number of parameters in deep CNN architectures, intensive computing resources are required to train these models. Additionally, chest x-ray datasets are often rather tiny, and there is always the risk of overfitting when developing a model. In this dissertation, we propose five convolutional neural networks (CNNs) to identify illness and segment the lungs in chest x-rays. New Line, New Line In the first research paper, an adaptive lightweight convolutional neural network (ALCNN) is created to detect pneumothorax with few parameters. The model readjusts the feature calibration channel-wise using the convolutional layer and attention mechanism. The suggested model outperformed state-of-the-art deep models trained using three different transfer learning methods. One notable aspect of the suggested model is that it requires ten times less parameters than the best deep models currently available. The second paper suggests the FocusCovid methodology for identifying COVID-19. © 2023 IEEE.

A Garden of Marvels: Tales of Wonder from Early Medieval China by Robert Ford Campany (review)

The category of zhiguai (accounts of the strange) texts is diverse, encompassing a wide variety of anecdotes, historical records, memoirs, letters, temple inscriptions, and biographies, among others, that recount encounters with sacred, ordinary, and apotropaic objects, shapeshifting animals, ghosts, demons, local gods, and numinous beings such as Daoist transcendents or the Buddha, Buddhist practitioners, deities and supernatural creatures;visits to otherworldly places such as the court of judgment in the afterlife, hidden villages of immortals or enlightened beings à la James Hilton's Shangri-la or the Tibetan mythical kingdom of Shambhala, or even heaven or hell;and unaccountable phenomena such as bizarre dreams, premonitions, and miraculous occurrences, including surviving entombment and the return from death (xxviii). Mordicai Gerstein's children's book Carolinda Clatter (2005), with its description of a giant's sleeping body becoming a mountain with forests, caves, and waterfalls, mirrors the cosmogonic myth of Pangu, whose body parts become the world in item 85 (58 and 59). The eerie feel of the scene in C. S. Lewis's The Magician's Nephew (1955), where Digory Kirke enters the Garden to pluck an apple from the Tree of Knowledge to protect Narnia, is highly reminiscent of item 47 (35), where uninvited intruders eat their fill of otherworldly fruit from a remote orchard but are admonished by an unseen voice in midair to drop the fruit they intended to take with them.

Towards Understanding the COVID-19 Specific Patterns in Lung CT Scan Images using Deep CTNET Framework

Automated diagnosis of COVID-19 based on CTScan images of the lungs has caught maximum attention by many researchers in recent times. The rationale of this work is to exploit the texture patterns viz. deep learning networks so that it reduces the intra-class similarities among the patterns of COVID-19, Pneumonia and healthy class samples. The challenge of understanding the concurrence of the patterns of COVID-19 with other closely related patterns of other lung diseases is a new challenge. In this paper, a fine-tuned variational deep learning architecture named Deep CT-NET for COVID-19 diagnosis is proposed. Variation modelling to Deep CT-NET is evaluated using Resnet50, Xception, InceptionV3 and VGG19. Initially, grey level texture features are exploited to understand the correlation characteristics between these grey level patterns of COVID-19, Pneumonia and Healthy class samples. CT scan image dataset of 20,978 images was used for experimental analysis to assess the performance of Deep CT-NET viz., all mentioned models. Evaluation outcomes reveals that Resnet50, Xception, and InceptionV3 producing better performance with testing accuracy more than 96% in comparison with VGG19. © 2022 IEEE.

Classification of Lung CT Scan Images using Machine Learning

Timely discovery of COVID-19 may safeguard numerous diseased people. Several such lung diseases can turn to be life threatening. Early detection of these diseases can help in treating them at an early stage before it becomes threatening. In this paper, the proposed 3D CNN model helps in classifying the CT scans as normal and abnormal, which can then be used to treat the patients after recognizing the diseases. Chest X-ray is fewer commanding in the initial phases of the sickness, while a CT scan of the chest is advantageous even formerly symptoms seem, and CT scan accurately identify the anomalous features which are recognized in images. Besides this, using the two forms of images will raise the database. This will enhance the classification accuracy. In this paper the model used is a 3D CNN model;using this model the predictions are done. The dataset used is acquired from NKP Salve Medical Institute, Nagpur. This acquired dataset is used for prediction while an open source database is used for training the CNN model. After training the model the prediction were successfully completed, with these proposed 3D CNN model total accuracy of 87.86% is achieved. This accuracy can further be increased by using larger dataset. © 2022 IEEE.

Improved Residual U-Net for COVID-19 Lung Infection Multi-Class Segmentation in CT Image

COVID-19, the new coronavirus, is a threat to global public health. Today, there is an urgent need for automatic COVID-19 infection detection tools. This work proposes an automatic COVID-19 infection detection system based on CT image segmentation. A deep learning network developed from an improved Residual U-net architecture extracts infected areas from a CT lung image. We tested the system on COVID-19 public CT images. An evaluation using the F1 score, sensitivity, specificity and accuracy proved the effectiveness of the proposed network. Besides, experimental results showed that the proposed network performed well in extracting infection regions so, it can assist experts in COVID-19 infection detection. © 2022 IEEE.

Convolutional Neural Networks for Detection of COVID-19 from Chest X-Rays

The coronavirus (COVID-19) pandemic was rapid in its outbreak, and the contagion of the virus led to an extensive loss of life globally. This study aims to propose an efficient and reliable means to differentiate between chest x-rays indicating COVID-19 and other lung conditions. The proposed methodology involved combining deep learning techniques such as data augmentation, CLAHE image normalization, and transfer learning with eight pre-trained networks. The highest performing networks for binary, 3-class (normal vs. COVID-19 vs. viral pneumonia) and 4-class classifications (normal vs. COVID-19 vs. lung opacity vs. viral pneumonia) were MobileNetV2, InceptionResNetV2, and MobileNetV2, achieving accuracies of 97.5%, 96.69%, and 92.39%, respectively. These results outperformed many state-of-the-art methods conducted to address the challenges relating to the detection of COVID-19 from chest x-rays. The method proposed can serve as a basis for a computer-aided diagnosis (CAD) system to ensure that patients receive timely and necessary care for their respective illnesses. Copyright © 2022, IGI Global.